Sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) is a small tree or bush. It belongs to the\nElaeagnaceae family, and has been used for many years in traditional medicine in both Europe and\nAsia. However, there is no data on the effect of sea buckthorn leaves and twigs on the properties\nof blood platelets. The aim of the study was to analyze the biological activity of phenolic extracts\nfrom leaves and twigs of sea buckthorn in blood platelets in vitro. Two sets of extracts were used: (1)\nphenolic compounds from twigs and (2) phenolic compounds from leaves. Their biological effects on\nhuman blood platelets were studied by blood platelet adhesion, platelet aggregation, arachidonic acid\nmetabolism and the generation of superoxide anion. Cytotoxicity was also evaluated against platelets.\nThe action of extracts from sea buckthorn twigs and leaves was compared to activities of the phenolic\nextract (a commercial product from the berries of Aronia melanocarpa (Aronox®) with antioxidative\nand antiplatelet properties. This study is the first to demonstrate that extracts from sea buckthorn\nleaves and twigs are a source of bioactive compounds which may be used for the prophylaxis and\ntreatment of cardiovascular pathologies associated with blood platelet hyperactivity. Both leaf and\ntwig extracts were found to display anti-platelet activity in vitro. Moreover, the twig extract (rich in\nproanthocyanidins) displayed better anti-platelet potential than the leaf extract or aronia extract.
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